"Dog X Cat" is a manga series that blends elements of romance, comedy, and supernatural themes. The story centers around two main characters, Juta Shirogane and Aoi Sakuraba, whose lives become intertwined due to a mysterious curse. Juta is a carefree and somewhat lazy high school student who harbors a secret: he transforms into a dog whenever he is kissed by a girl. This peculiar condition stems from a curse placed on his family, which has persisted for generations. Aoi, on the other hand, is a diligent and responsible classmate who, unbeknownst to her, carries a similar curse that causes her to transform into a cat when kissed by a boy.

The narrative unfolds as Juta and Aoi accidentally discover each other's curses during a series of comedic and awkward encounters. Their mutual predicament forces them to navigate their daily lives with caution, as any romantic or accidental kiss could trigger their transformations. Despite their initial reluctance, the two form a bond as they work together to find a way to break the curses. Their journey is filled with humorous situations, misunderstandings, and moments of vulnerability as they grow closer.

Supporting characters add depth to the story, including Juta's childhood friend, Rino, who harbors feelings for him, and Aoi's protective older brother, who is wary of Juta's intentions. The dynamic between Juta and Aoi evolves from one of reluctant cooperation to genuine affection, as they confront their fears and insecurities. The series explores themes of identity, self-acceptance, and the complexities of relationships, all while maintaining a lighthearted and comedic tone.

As the story progresses, Juta and Aoi uncover more about the origins of their curses and the possibility of breaking them. Their quest leads them to confront supernatural elements and delve into their family histories, revealing connections that tie their fates together. The manga balances its supernatural premise with relatable emotional struggles, creating a narrative that is both entertaining and heartfelt.