Manabi Mizuno is a Japanese voice actress and singer born on July 27, 1977, in Gunma Prefecture, Japan. She began her entertainment career in 1995 participating in musical theater productions. In 1996, she successfully passed a talent search conducted by Pioneer LDC, after which she began using the stage name Manabi Mizuno for her voice acting activities. Her anime voice acting debut came in 1997 with a role in the television series Shin Tenchi Muyo. She is a graduate of Ferris University's Faculty of Letters, where she studied in the Department of Japanese Literature.

Throughout her career, Mizuno has been affiliated with several talent management agencies. Her professional engagements include Pioneer Music Works from her debut until 2000, I'm Enterprise from 2000 to 2003, and Versatile Entertainment from 2003 to 2005. After periods as a freelance performer, she joined Kaleidoscope in 2006, later became affiliated with EARLY WING in 2010, and has been associated with Studio Gate since 2021.

Mizuno has built a diverse portfolio of voice roles in anime television series. Among her notable early performances was the role of Juri Kato in the influential 1998 series Serial Experiments Lain. In 2001, she voiced Rin Todoroki in Mahoromatic: Automatic Maiden. She played Midori in the 2002 series Haibane Renmei. In the 2004 television series This Ugly Yet Beautiful World, she provided the voice for the character Sakurako Urushima. Other anime credits include roles in Gokudou-kun Manyuuki, Nazca, St. Luminous Mission High School, Boys Be..., Zoids Fuzors, Great Dangaioh, Seven of Seven, and Higurashi: When They Cry.

Beyond anime, Mizuno's work extends to video game voice acting. Her game credits include the role of Desco in Disgaea 4, Kaila Kirsten in Baldr Force EXE, and Amy in Zoids Infinity. She also performed in the game The White-colored Love Syndrome.

Mizuno has also pursued a career as a singer. She made her solo singing debut in 1998 with the single Hurdle. She has contributed theme song performances to anime series, including the ending theme for the 1998 series Jikuu Tantei Genshi-kun. In 2006, she formed the musical unit Plume with fellow voice actresses Aya Endo and Shizuka Kawaragi. The group began as a doujin circle and made a major label debut in 2008 with the album Kimi to Yume to Amburera released by Lantis. Her biography notes that she has studied both classical ballet and jazz dance, and lists cooking, film and theater appreciation, cocktail mixing, and blowing soap bubbles as her hobbies and skills. Available sources do not document voice roles for the characters Tamamo Kitsune in Cream Lemon: New Generation or Kii-chan in Onnanoko Monogatari, as mentioned in the query, nor do they indicate recurring creative collaborations with specific directors or fellow cast members beyond standard professional casting.