"Cleopatra D.C." is a three-episode OVA series set in a futuristic, cyberpunk-inspired world where advanced technology and societal decay coexist. The story revolves around Cleopatra, a skilled and enigmatic bounty hunter who operates in the sprawling metropolis of Neo-Tokyo. Known for her sharp intellect, combat prowess, and striking appearance, Cleopatra is hired by various clients to track down and eliminate high-profile targets, often navigating the morally ambiguous underworld of the city.

The narrative begins with Cleopatra accepting a contract to capture a rogue scientist, Dr. K, who has developed a dangerous bioweapon capable of causing mass destruction. As she delves deeper into the mission, Cleopatra uncovers a conspiracy involving powerful corporations and corrupt government officials who seek to exploit the bioweapon for their own gain. Along the way, she encounters a diverse cast of characters, including rival bounty hunters, cybernetically enhanced assassins, and a mysterious informant who provides crucial information about Dr. K's whereabouts.

The series explores themes of power, corruption, and survival in a dystopian society where the line between humanity and technology is increasingly blurred. Cleopatra's journey is marked by intense action sequences, strategic planning, and moments of introspection as she confronts the ethical dilemmas of her profession. The plot is driven by her determination to complete her mission while navigating the treacherous landscape of Neo-Tokyo, where betrayal and danger lurk around every corner.

The main characters include Cleopatra, whose past remains shrouded in mystery, and Dr. K, whose motivations and actions are central to the unfolding conspiracy. Supporting characters such as Cleopatra's informant and her adversaries add depth to the narrative, highlighting the complex relationships and alliances that define the world of "Cleopatra D.C." The series concludes with a climactic confrontation that resolves the immediate conflict but leaves room for further exploration of the characters and their world.