"Zo Zo Zombie" centers around a young boy named Yohei, who becomes a zombie after being bitten by a mysterious creature. Despite his transformation, Yohei retains his human consciousness and continues to live a relatively normal life, attending school and interacting with his friends. However, his zombie nature often leads to comedic and chaotic situations, as he struggles to hide his condition while dealing with his insatiable hunger for brains. Yohei’s best friend, Kazuo, is aware of his secret and helps him navigate the challenges of being a zombie, often devising creative solutions to prevent Yohei from revealing his true nature.

The series explores Yohei’s daily life as he balances his zombie instincts with his desire to maintain his humanity. His interactions with classmates, teachers, and other characters frequently result in humorous scenarios, particularly when his hunger for brains becomes overwhelming. The narrative also introduces various supernatural elements, such as other zombies and creatures, adding layers of complexity to Yohei’s struggles. Throughout the series, themes of friendship, identity, and acceptance are subtly woven into the comedic framework, as Yohei and Kazuo work together to overcome obstacles and protect Yohei’s secret.

The main characters include Yohei, the zombie protagonist who strives to live a normal life despite his condition; Kazuo, his loyal and resourceful best friend who supports him unconditionally; and a cast of classmates and teachers who remain oblivious to Yohei’s true nature, often contributing to the comedic misunderstandings that drive the plot. The series maintains a lighthearted tone, blending humor with occasional moments of tension as Yohei’s secret is repeatedly threatened with exposure. The episodic structure allows for a variety of scenarios, each highlighting different aspects of Yohei’s dual existence as both a zombie and a human.