"My Honey is College School Gal" centers on the romantic and comedic interactions between a high school student and a college-aged gyaru. The protagonist, a reserved and studious high school boy, finds his life turned upside down when he becomes the object of affection for a lively and outgoing college girl. Their relationship begins unexpectedly, often fueled by her bold and forward advances, which contrast sharply with his shy and awkward demeanor. The dynamic between the two characters drives much of the series' humor and emotional moments, as they navigate the challenges of their age gap, differing lifestyles, and social expectations.

The college girl, characterized by her trendy fashion, confident personality, and playful teasing, frequently takes the lead in their relationship, often putting the high school boy in situations that test his comfort zone. Despite her seemingly carefree attitude, she reveals moments of vulnerability and depth, particularly as the story explores her reasons for pursuing him and her own insecurities about their relationship. The high school boy, while initially overwhelmed by her attention, gradually develops feelings for her, though his inexperience and self-doubt create obstacles in their budding romance.

The narrative unfolds through a series of episodic encounters, blending lighthearted comedy with occasional heartfelt moments. Supporting characters, including friends and classmates from both the high school and college settings, add further layers to the story, often providing advice, misunderstandings, or comedic relief. Themes of self-discovery, communication, and the complexities of young love are woven into the plot, as the two protagonists learn to bridge the gap between their worlds and understand each other's perspectives.

The series balances its comedic tone with moments of genuine emotional connection, offering a mix of slapstick humor, romantic tension, and character growth. While the central focus remains on the evolving relationship between the high school boy and the college girl, the story also touches on broader themes of personal growth and the challenges of navigating relationships across different stages of life.