"Yuri Seijin Naoko-san" is a short-form anime series based on the manga by Miman. The narrative centers on Naoko, an alien from the planet Yuri, who arrives on Earth with the mission to promote yuri (girls' love) relationships among humans. Naoko frequently visits Earth to observe and interact with a middle school girl named Aikawa, whom she has chosen as her primary subject. Naoko's eccentric and over-the-top personality often leads to humorous and surreal situations as she attempts to encourage romantic feelings between Aikawa and her classmates.

Aikawa, the human protagonist, is a reserved and somewhat skeptical girl who finds herself constantly bewildered by Naoko's antics. Despite her initial reluctance, Aikawa gradually becomes accustomed to Naoko's presence, though she remains unsure of how to respond to the alien's persistent efforts to spark yuri relationships. The dynamic between Naoko and Aikawa forms the core of the series, with Naoko's exaggerated enthusiasm contrasting sharply with Aikawa's grounded and pragmatic demeanor.

The series is episodic in nature, with each short episode focusing on Naoko's various schemes to promote yuri themes, often involving Aikawa and her classmates. These schemes range from distributing yuri-themed propaganda to orchestrating contrived romantic scenarios. The humor arises from the absurdity of Naoko's methods and the reactions of the human characters, particularly Aikawa, who frequently questions the logic and feasibility of Naoko's plans.

Supporting characters include Aikawa's classmates, who occasionally become unwitting participants in Naoko's experiments. These characters add variety to the interactions and provide additional comedic moments as they react to Naoko's unconventional behavior. The series maintains a lighthearted and comedic tone throughout, with no overarching plot but rather a series of self-contained vignettes that highlight the quirky relationship between Naoko and Aikawa.

"Yuri Seijin Naoko-san" is characterized by its brevity and focus on humor, with each episode running only a few minutes. The series does not delve deeply into character development or complex storytelling, instead prioritizing quick, comedic scenarios that play on the contrast between Naoko's alien perspective and the more mundane reality of human life. The result is a whimsical and entertaining exploration of yuri themes through the lens of an alien's misguided but well-intentioned efforts.