"HIMOTE HOUSE: A Share House of Super Psychic Girls" centers on a group of young women living together in a Tokyo share house, each possessing unique psychic abilities. The main characters include Kokoro, a high school student with the power of telekinesis; Nakamaru, a college student who can read minds; Tae, a NEET with precognitive dreams; Himote, a shut-in who can astral project; and Minamo, a housewife with teleportation abilities. The series explores their daily lives as they navigate the challenges of coexisting while dealing with their extraordinary powers.

The narrative unfolds in a comedic and slice-of-life format, with each episode focusing on the girls' interactions and the humorous situations that arise from their psychic abilities. The share house becomes a hub for both mundane and supernatural events, blending everyday activities like cooking and cleaning with fantastical elements such as time travel, ghost encounters, and interdimensional adventures. The characters' personalities and quirks often clash, leading to chaotic yet lighthearted scenarios.

Throughout the series, the girls face external threats, including rival psychics and mysterious organizations seeking to exploit their powers. These conflicts are resolved through teamwork and creative use of their abilities, reinforcing the theme of camaraderie. Despite their differences, the residents of Himote House form a close-knit group, supporting one another through both ordinary and extraordinary challenges. The series balances humor, supernatural elements, and character-driven storytelling, offering a unique take on the slice-of-life genre.