"Nurse Me!" is a short-form anime series that blends comedy and slice-of-life elements with a medical twist. The story centers around a group of anthropomorphic animal nurses who work at the Animal Medical Center, a bustling hospital catering to a variety of animal patients. Each episode is structured around the daily challenges and humorous situations the nurses face as they care for their patients, often highlighting the quirks and personalities of both the staff and the animals they treat.

The main characters include a diverse cast of nurses, each representing a different animal species. The lead nurse is a diligent and caring rabbit named Sakura, who often takes charge in critical situations. Alongside her is a laid-back and somewhat clumsy panda nurse named Mei, whose relaxed demeanor contrasts with Sakura's seriousness. A fox nurse named Rin adds a mischievous yet skilled presence to the team, while a shy but highly competent penguin nurse named Yuki rounds out the core group. The hospital's chief, a stern but wise owl named Dr. Hoot, oversees the team and provides guidance when needed.

The episodic nature of the series allows for a variety of medical scenarios, ranging from routine check-ups to more urgent cases, all infused with lighthearted humor and occasional moments of heartfelt care. The interactions between the nurses and their patients often serve as the focal point, showcasing the unique challenges of treating different species while maintaining a comedic tone. Despite the fantastical premise of animal nurses, the series incorporates realistic medical procedures and ethical dilemmas, adding a layer of educational value to its entertainment.

The narrative emphasizes teamwork, compassion, and the importance of adaptability in a high-pressure environment. While the series primarily aims to entertain, it occasionally touches on themes of empathy and the human-animal bond, albeit in a simplified and humorous manner. The brevity of each episode ensures a fast-paced and engaging viewing experience, making it accessible to a wide audience.