"Hyakushō Kizoku" centers on the life of a young man named Hachiken Yuugo, who enrolls at Ooezo Agricultural High School in rural Hokkaido to escape the pressures of his academic-focused upbringing. Initially unfamiliar with farming, Hachiken struggles to adapt to the demanding physical labor and the unique challenges of agricultural life. The series explores his gradual immersion into the world of farming, highlighting his interactions with classmates who have grown up in agricultural families and possess deep knowledge of the field.

The narrative is structured around Hachiken's daily experiences at the school, where he learns about livestock care, crop cultivation, and the economic realities of running a farm. His classmates, including the hardworking Mikage Aki and the passionate Komaba Ichirou, serve as both mentors and peers, helping him navigate the complexities of agricultural work. Through these relationships, Hachiken gains a deeper appreciation for the dedication and resilience required in farming.

As the story progresses, Hachiken's initial reluctance transforms into genuine interest and respect for the agricultural lifestyle. The series delves into themes of perseverance, community, and the interconnectedness of humans and nature. It also addresses broader societal issues, such as the challenges faced by small-scale farmers and the importance of sustainable practices.

The episodic structure of "Hyakushō Kizoku" allows for a detailed exploration of various aspects of farming, from the care of animals like pigs and horses to the intricacies of growing vegetables and managing farm equipment. Each episode often focuses on a specific task or challenge, providing educational insights while advancing Hachiken's personal growth.

By the end of the series, Hachiken emerges as a more confident and capable individual, having forged strong bonds with his classmates and developed a newfound respect for the agricultural profession. The story concludes with a sense of fulfillment, as Hachiken reflects on his journey and the lessons he has learned, leaving viewers with a deeper understanding of the agricultural world and its significance.