"Shikizakura" is a 12-episode anime series that blends action, science fiction, and supernatural elements. The story is set in a world where humanity faces a threat from mysterious entities known as "Oni," which emerge from a parallel dimension. These Oni possess humans, turning them into dangerous monsters. To combat this threat, a specialized organization called the Oni Slayer Corps employs advanced technology and warriors equipped with powered suits known as "Shikizakura Armor." These suits grant their wearers enhanced abilities, allowing them to fight the Oni effectively.

The protagonist, Kakeru Miwa, is a high school student who becomes involved in the conflict after encountering an Oni attack. During the incident, he discovers his latent ability to synchronize with the Shikizakura Armor, a rare trait that makes him a valuable asset to the Oni Slayer Corps. Kakeru is recruited into the organization and begins training alongside other warriors, including the skilled and determined Rino Hanamizawa, who serves as his mentor and guide. Together, they work to protect humanity from the Oni threat.

As the series progresses, Kakeru and his allies uncover deeper mysteries surrounding the Oni and their origins. The narrative explores themes of sacrifice, teamwork, and the struggle to maintain humanity in the face of overwhelming odds. The characters face personal challenges and moral dilemmas, particularly as they confront the human hosts of the Oni, who are often innocent victims. The story builds toward a climactic confrontation with the Oni's true mastermind, revealing the extent of the danger posed to both worlds.

The series features a mix of intense action sequences, character-driven drama, and world-building, with a focus on the relationships between the members of the Oni Slayer Corps. The Shikizakura Armor, central to the plot, symbolizes the fusion of human determination and technological innovation in the fight against a seemingly insurmountable foe. The anime balances its supernatural and sci-fi elements with a grounded exploration of its characters' motivations and growth, making it a compelling entry in the action genre.