"Moekan" centers around a group of young girls who form a club dedicated to creating and performing in their own anime. The narrative unfolds in a high school setting, where the protagonist, Aoi, a passionate anime enthusiast, decides to establish the Moekan Club after realizing there is no existing club that aligns with her interests. She recruits several classmates, each with distinct personalities and skills, to join her in this endeavor.

The club members include Yui, a talented artist with a reserved demeanor; Rina, a tech-savvy programmer who handles the technical aspects of animation; and Miku, a cheerful and energetic girl who excels in voice acting. Together, they navigate the challenges of creating an anime from scratch, balancing their schoolwork, personal lives, and the demands of their ambitious project. The series highlights their collaborative efforts, creative processes, and the occasional conflicts that arise as they work toward their goal.

Throughout the series, the girls face various obstacles, such as tight deadlines, creative differences, and the pressure to produce high-quality work. They also encounter rival clubs and external critics who challenge their abilities and determination. Despite these hurdles, the Moekan Club members grow closer, learning to trust and support one another. Their journey is marked by moments of triumph and setbacks, ultimately culminating in the completion of their first anime project, which they present at a school festival.

The narrative emphasizes themes of friendship, perseverance, and the pursuit of creative passions. It provides a detailed look into the anime production process, offering insights into character design, storyboarding, voice recording, and animation techniques. The series also explores the personal growth of each character, as they overcome insecurities and develop their skills, both individually and as a team. "Moekan" presents a realistic portrayal of the challenges and rewards of creating art, set against the backdrop of high school life.