"Ganbare Genki" is a sports anime centered around boxing, adapted from the manga by Yū Koyama. The story revolves around Genki Horiguchi, a young boy who aspires to become a professional boxer, inspired by his father, Ryūma Horiguchi, a former boxing champion. After Ryūma's untimely death, Genki dedicates himself to fulfilling his father's dream of winning a world title. Despite his small stature and lack of natural talent, Genki's determination and relentless training drive him to overcome numerous challenges.

The narrative follows Genki's journey from a novice to a skilled boxer, highlighting his growth through intense training and competitive matches. Along the way, he encounters various rivals and mentors who shape his development. Key characters include Genki's mother, who supports his ambitions despite her initial reservations, and his childhood friend Yūko, who provides emotional encouragement. Genki's rivalry with Takaomi Katsuragi, a talented and arrogant boxer, serves as a central conflict, pushing Genki to improve and prove his worth.

The series emphasizes themes of perseverance, hard work, and the pursuit of dreams, portraying the physical and emotional struggles of a young athlete striving to succeed in a demanding sport. Through its focus on boxing matches and training sequences, "Ganbare Genki" captures the intensity and discipline required in competitive sports, while also exploring the personal relationships and motivations that drive its characters. The story balances action with emotional depth, offering a compelling portrayal of Genki's journey toward achieving his goals.