"Wife with Wife" centers on the lives of two women, Yuna and Rika, who find themselves in an unconventional living arrangement after their respective husbands unexpectedly pass away. Both women, now widows, are left to navigate their grief while managing the responsibilities of their households. The story begins when Yuna, a reserved and traditional homemaker, moves into Rika’s home to share living expenses and support each other emotionally. Rika, in contrast, is more outgoing and career-driven, working as a freelance writer. Their differing personalities initially create friction, but over time, they develop a deep bond as they learn to rely on one another.

The narrative explores their daily lives as they adjust to their new reality, balancing household chores, financial struggles, and societal expectations. Yuna’s meticulous nature often clashes with Rika’s more laid-back approach, leading to humorous and heartfelt moments. As the series progresses, the two women confront their pasts, including unresolved feelings about their late husbands and the challenges of moving forward. Themes of friendship, resilience, and self-discovery are woven throughout the story, as Yuna and Rika gradually find strength in their partnership.

Supporting characters include their neighbors and coworkers, who provide additional layers to the story by offering advice, creating conflicts, or serving as foils to the main characters. The series also delves into the societal pressures faced by widows in Japan, highlighting the stigma and expectations placed on women in their position. Through its episodic structure, "Wife with Wife" balances lighthearted moments with poignant reflections on loss and healing, creating a narrative that is both relatable and emotionally resonant. The dynamic between Yuna and Rika remains the core focus, showcasing how their evolving relationship helps them navigate life’s challenges and rediscover their individual identities.