"Guyver: Out of Control" is a 1986 OVA adaptation of Yoshiki Takaya's manga "Bio Booster Armor Guyver." The narrative centers on Sho Fukamachi, a high school student who inadvertently becomes the host of the Guyver Unit, a powerful bio-mechanical armor created by an ancient alien race. The Guyver Unit bonds with Sho, granting him immense strength, regenerative abilities, and advanced weaponry, but also making him a target for the Chronos Corporation, a secretive organization seeking to reclaim the unit for their own purposes.

Chronos is revealed to be a global syndicate controlled by the Zoanoids, genetically engineered human-alien hybrids created by the same alien race that designed the Guyver. The organization aims to dominate humanity by transforming humans into Zoanoids and eliminating any threats to their plans. Sho's possession of the Guyver Unit disrupts their agenda, leading to a series of violent confrontations. As Sho struggles to control the Guyver's power, he is pursued by Chronos agents, including the ruthless Enzyme and the enigmatic Commander Balcus.

The story explores themes of identity, power, and survival as Sho grapples with his new role as the Guyver. His transformation alienates him from his peers and places his loved ones in danger, particularly his friend Tetsuro Segawa and his love interest, Mizuki Segawa. The narrative intensifies as Sho uncovers the truth about Chronos and the origins of the Guyver, culminating in a climactic battle against powerful Zoanoid adversaries. The OVA's plot is fast-paced, focusing on action and the moral dilemmas faced by Sho as he navigates his dual existence as both a human and a weapon of immense destructive potential.