Ayaka Sanders, a genetically engineered teenager, was saved from terminal heart disease by her father, Dr. James Sanders, through an experimental procedure injecting pluripotent stem cells from Shinichi Kuruma’s bone marrow. Unbeknownst to her, this act forged a psychic bond with Shinichi—a deliberate design by the 13 Doctors, a clandestine group led by Dr. Genzou Kuruma, to resurrect a revered deity.

Her body now generates the "blood of Maria," a vital catalyst for the deity’s revival, marking her as a target for the Doctors’ harvesting efforts. This connection embroils her in clashes with New Humans—genetically altered beings capable of monstrous transformations—who relentlessly pursue her, forcing Shinichi to repeatedly shield her from harm.

Dr. Sanders’ dual identity as Dr. Jacob, a member of the 13 Doctors, entangles her existence in a web of scientific ambition and ideological warfare. The cure that spared her life binds her to Shinichi’s vengeful crusade against Genzou, whose unethical experiments shattered Shinichi’s family.

A pivotal kidnapping attempt by the Doctors triggers an unforeseen phenomenon: a radiant beam erupts from Ayaka’s body, unveiling dormant abilities or a profound tie to the deity’s resurrection. This moment shifts her trajectory from passive vessel to active participant in the escalating conflict.

The psychic link with Shinichi deepens, bridging their emotions and visions, shaping their choices and fortifying their alliance against the Doctors. Though thrust into a realm of violence and supernatural forces, Ayaka’s resilience as a survivor and her unwitting centrality to an apocalyptic gambit anchor her journey, defining her evolution from a cured patient to a pivotal figure in a battle spanning science, divinity, and survival.