Misae Nohara anchors the Nohara family as its matriarch, originally from Aso in Kumamoto Prefecture and sister to Masae and Musae Koyama. As a full-time homemaker, she manages cleaning, laundry, cooking, and childcare with fluctuating success. She consistently claims an age of 24-25 despite actually being 29.

Her behavior reveals stark contradictions: she imposes strict household rules yet flouts them in private, enforcing rigorous budgets while compulsively hoarding impractical bargain-sale items. Secret savings stashed away face occasional family raids during financial crises. Disciplinary measures involve physical comedy like the "Guri-Guri Attack" (head drilling) and exaggerated head punches.

When supernatural darkness orbs emerge, Misae’s maternal instincts surge after infant daughter Himawari swallows one. Drawn into an involuntary odyssey with Hiroshi, Shinnosuke, and Himawari, she battles the pursuing Tamayumi clan to protect Himawari. After the clan abducts Himawari, Misae confronts antagonists directly, storming their Rainbow Bridge-adjacent high-rise with Hiroshi, Shinnosuke, and allies to reclaim her daughter.

Though she collaborates with Hiroshi in emergencies, friction arises over finances and trust. Resource allocation favors Himawari over Hiroshi and Shinnosuke. Technologically limited, Misae confines employment to part-time retail—roles she fails to sustain due to inconsistent conduct.