Driving along a dark mountain road, a young doctor named Kazue accidentally hits a naked girl. When she stops to help, the girl mysteriously gets up and flees into the woods without a word. Kazue follows her to an abandoned mansion hidden in a forest clearing, but instead of finding the accident victim, she discovers a different young woman named Yukiko, wrapped in a sleeping bag and near death, alongside a disturbing scene involving a screaming man and a video camera. Kazue rescues Yukiko and brings her to the clinic where she works.

One year later, Kazues life is interrupted by federal investigators who have arrived to question her about the naked girl from the mountain road. They explain that the girl she encountered is Tomie Kawakami, a mysterious young woman identified by a beauty mark under her left eye, who is connected to a series of bizarre and violent crimes. The investigators reveal the horrifying truth about Tomie: she is an immortal being whose individual cells can regenerate into complete new bodies, allowing her to take over the bodies of others to resurrect herself. Because her corpse never stays dead, there are no autopsy records, and a murder inevitably follows wherever she appears.

As Kazue is drawn deeper into the investigation, she realizes that the key to unraveling the mystery of Tomie lies in the video camera she found in the abandoned house. The footage recorded that night holds the answers she needs, but unlocking them puts her directly in Tomies path. The immortal girl begins her ritual of revenge, and Kazue finds herself trapped in a nightmare where the line between savior and victim blurs. She must confront the terrifying reality that Tomie is not just a person to be found or stopped, but a curse that corrupts and multiplies, turning those who encounter her into either pawns or prey in her endless cycle of death and regeneration.