"Tōdai o Detakeredo - Mah-Jong ni Tsukareta Otoko" centers on the life of a man named Shigeru, a former University of Tokyo graduate whose promising academic trajectory takes an unexpected turn due to his obsession with mahjong. Shigeru, once a diligent and ambitious student, becomes consumed by the game, leading to a series of personal and professional setbacks. His addiction to mahjong disrupts his career, relationships, and overall stability, painting a stark picture of how a seemingly harmless pastime can spiral into a destructive force.

The narrative explores Shigeru's struggles as he navigates the highs and lows of his addiction. His journey is marked by moments of fleeting triumph at the mahjong table, contrasted with the harsh realities of his deteriorating life outside of it. The story delves into the psychological grip of gambling, portraying how Shigeru's initial fascination with mahjong evolves into a compulsion that overshadows his responsibilities and aspirations.

Key characters include Shigeru's peers and acquaintances, who serve as foils to his downward spiral. These individuals highlight the contrast between Shigeru's wasted potential and their own measured successes, further emphasizing the consequences of his choices. The manga also features various mahjong players who intersect with Shigeru's life, each representing different facets of the game's allure and its impact on those who become entangled in its world.

The plot is structured around Shigeru's attempts to regain control of his life, interspersed with flashbacks that provide context for his descent into addiction. These flashbacks reveal pivotal moments where Shigeru's decisions to prioritize mahjong over his studies, career, and personal relationships set the stage for his eventual downfall. The story does not shy away from depicting the gritty realities of gambling addiction, offering a candid portrayal of its effects on Shigeru's mental health, social standing, and future prospects.

Through its exploration of Shigeru's life, the manga provides a nuanced examination of the fine line between passion and obsession, as well as the societal pressures and personal vulnerabilities that can lead to self-destructive behavior. The narrative remains grounded in its portrayal of mahjong as both a game of skill and a potential catalyst for ruin, making it a compelling study of human frailty and resilience.