"Neko-ka Danshi no Shitsukekata" centers on the life of Chiharu, a young woman who unexpectedly becomes the caretaker of a group of cat-like boys known as the Neko-ka Danshi. These boys, each possessing feline traits and personalities, are the result of a mysterious experiment conducted by a secretive organization. Chiharu’s journey begins when she stumbles upon one of the boys, Haru, who is injured and in need of help. After taking him in, she discovers his unique nature and learns about the existence of others like him.

The narrative explores Chiharu’s efforts to provide a safe and nurturing environment for the Neko-ka Danshi, who struggle to adapt to human society due to their animal instincts and lack of social experience. Each boy has distinct characteristics tied to their feline traits: Haru is affectionate and loyal, Kuro is aloof and independent, Shiro is playful and mischievous, and Tora is bold and protective. Their interactions with Chiharu and the world around them form the core of the story, blending moments of humor, warmth, and occasional tension as they navigate their dual identities.

As the series progresses, Chiharu uncovers more about the organization responsible for creating the Neko-ka Danshi, revealing darker aspects of their origins. The boys’ pasts are gradually unveiled, highlighting their struggles with identity and the trauma of being treated as experiments. Chiharu’s determination to protect them and help them find a sense of belonging drives the emotional core of the narrative. The story balances slice-of-life elements with underlying themes of family, acceptance, and the ethical implications of scientific experimentation.

The dynamic between Chiharu and the Neko-ka Danshi evolves as they learn to trust and rely on one another, creating a makeshift family bound by mutual care and understanding. The series delves into their individual growth, as well as their collective journey toward finding a place where they can live freely and authentically. Through its exploration of human-animal hybrid identities and the bonds formed between its characters, "Neko-ka Danshi no Shitsukekata" presents a heartfelt and engaging narrative.