"F no Meikyū" is a psychological thriller manga that explores themes of identity, memory, and the blurred line between reality and illusion. The narrative centers around a young man named Shun, who awakens in a mysterious, labyrinthine facility with no recollection of how he arrived there. The facility is filled with cryptic symbols, locked doors, and strange mechanisms, all of which seem to be part of an elaborate puzzle. Shun soon encounters other individuals trapped in the same environment, each with fragmented memories and their own motivations for escaping.

As Shun and the others navigate the maze, they uncover clues that suggest the facility is a construct designed to test their mental and emotional limits. The puzzles they encounter often require cooperation, but the group’s dynamics are strained by mistrust and conflicting agendas. Shun’s own memories begin to resurface in disjointed fragments, revealing a connection to the facility and its enigmatic creator, referred to only as "F." The deeper they delve into the labyrinth, the more they question the nature of their existence and the possibility that their memories may have been manipulated or fabricated.

The story is driven by its intricate plot twists and the psychological unraveling of its characters. Shun’s journey is marked by a growing sense of paranoia as he struggles to distinguish between reality and the illusions crafted by the facility. The other characters, including a resourceful woman named Rika and a secretive man named Kaito, each play pivotal roles in uncovering the truth behind the maze. Their interactions are fraught with tension, as alliances shift and hidden motives come to light.

The climax of the story reveals the true purpose of the facility: it is an experimental construct designed to explore the boundaries of human consciousness and the malleability of memory. Shun’s connection to "F" is revealed to be deeply personal, tying his fate to the ultimate resolution of the labyrinth’s mysteries. The ending leaves questions about the nature of identity and the consequences of tampering with the human mind, offering a thought-provoking conclusion to the series.