"Hokenshitsu no Ōkami Shōnen" centers on a high school infirmary nurse, Takeru Kirishima, who harbors a secret: he is a werewolf. Takeru works diligently to maintain a normal life while concealing his supernatural identity. His life takes a turn when a new student, Rino Fujimori, transfers to the school and becomes suspicious of his behavior. Rino, a perceptive and curious individual, begins to uncover Takeru's secret after witnessing unusual incidents tied to his condition.

The narrative explores Takeru's struggles with his dual nature, balancing his human side with the instincts and challenges of being a werewolf. His condition manifests during moments of stress or emotional turmoil, often leading to dangerous situations that threaten his secrecy. Rino, intrigued by Takeru's mysterious demeanor, becomes increasingly involved in his life, forming a bond that evolves into a complex relationship. Her presence forces Takeru to confront his fears and vulnerabilities, as she becomes both a confidante and a source of emotional support.

The story delves into themes of identity, acceptance, and the tension between humanity and primal instincts. Takeru's interactions with other characters, including classmates and school staff, reveal the challenges of living with a hidden truth. The series also incorporates elements of mystery and suspense, as Takeru's condition occasionally attracts unwanted attention, leading to conflicts that test his resolve and relationships.

As the plot progresses, Takeru and Rino navigate the complexities of their connection, with Rino's determination to understand and accept Takeru's true nature serving as a driving force. The series balances moments of tension and danger with quieter, introspective scenes that highlight the characters' emotional growth. Through its exploration of Takeru's dual existence and the impact of his secret on those around him, "Hokenshitsu no Ōkami Shōnen" presents a compelling narrative that intertwines supernatural elements with human drama.