Field Guide Bang Buddies: On the Prowl With My Trusty App! follows a protagonist navigating the modern world of casual encounters through a specialized smartphone application. The story centers on the use of this titular app, which serves as a field guide for identifying and connecting with potential partners, turning the often complicated social landscape of dating into a more systematic and game-like experience. The narrative explores the protagonist's various adventures and misadventures as they go on the prowl, using the app to locate and interact with a series of individuals.

The main character is a young adult who relies on the app to facilitate brief, no-strings-attached relationships. Each new encounter brings a different personality and situation, from chance meetings with strangers to more complicated entanglements with people who may not be as casual about the arrangement as initially assumed. The cast rotates as the protagonist moves from one liaison to the next, with recurring characters potentially including friends or rivals who also use the app, offering contrasting philosophies on love, intimacy, and modern technology.

The setting is a contemporary urban environment, likely a city with a vibrant nightlife and a high population density conducive to the app's matchmaking functions. Locations include trendy bars, apartments, and other spaces where adults in their twenties and thirties typically socialize. The app itself functions almost as a secondary character, providing a framework for the plot by sending notifications, suggesting matches, and creating a digital ecosystem that both enables and complicates the protagonist’s romantic life.

Notable narrative arcs involve the protagonist encountering a match that defies the app's usual superficial expectations, leading to an unexpected emotional connection that challenges the character’s commitment to a purely physical lifestyle. Another arc might involve a technical glitch or a malicious user that puts the protagonist in a socially awkward or potentially dangerous situation, forcing them to rely on instincts rather than the app's guidance. The story ultimately uses the app as a lens to examine themes of intimacy, disconnection, and the search for genuine human contact in an increasingly digital age. The manga is categorized for an adult audience, reflecting the mature nature of its premise and content.