"TenPuru -No One Can Live on Loneliness-" centers on Akemitsu Takamura, a young man raised in a strict, religious household with a father who is a monk. After his father's death, Akemitsu inherits the family temple but struggles with feelings of loneliness and a desire to connect with others. His life takes a dramatic turn when he encounters Yuzuki, a runaway girl who seeks refuge at the temple. Despite his initial reluctance, Akemitsu allows her to stay, setting the stage for a series of comedic and heartfelt interactions.

The narrative expands as more characters are introduced, each with their own quirks and backstories. Yuzuki, despite her tough exterior, harbors a kind heart and a desire to find her place in the world. Other key characters include Rin, a childhood friend of Akemitsu who harbors unspoken feelings for him, and various individuals who become intertwined with the temple's daily life. The story explores themes of companionship, personal growth, and the challenges of balancing tradition with modern life.

As Akemitsu navigates his responsibilities as a temple caretaker, he also grapples with his own insecurities and the complexities of his relationships. The interactions between the characters often lead to humorous situations, but the series also delves into more serious moments, highlighting the emotional struggles each character faces. The temple serves as a central setting where these dynamics unfold, providing a backdrop that blends the sacred with the mundane.

The plot progresses through a mix of episodic and overarching storylines, with each chapter contributing to the development of the characters and their relationships. The series balances lighthearted comedy with moments of introspection, creating a narrative that is both entertaining and thought-provoking. Through its exploration of themes like loneliness, belonging, and the importance of human connection, "TenPuru -No One Can Live on Loneliness-" offers a multifaceted look at the lives of its characters and the world they inhabit.