"Nekomimi×Kareshi" is a romantic comedy manga that explores the dynamics of relationships through a whimsical and fantastical lens. The story centers around a high school girl named Yuki, who discovers that her childhood friend and crush, Kouta, has developed cat-like features after a mysterious incident. Kouta now possesses cat ears and a tail, which he struggles to hide from others, adding a layer of comedic tension to their daily lives. Yuki, intrigued and amused by Kouta's new condition, decides to help him navigate this bizarre transformation while also grappling with her own feelings for him.

As the narrative progresses, the series delves into the challenges Kouta faces in maintaining his secret while dealing with the heightened senses and instincts that come with his feline traits. Yuki's support becomes crucial as Kouta's condition occasionally leads to awkward or humorous situations, particularly in social settings. The manga balances lighthearted moments with subtle romantic development, as Yuki and Kouta grow closer through their shared experiences.

The supporting cast includes classmates and friends who add depth to the story, often contributing to the comedic or dramatic elements. Some characters become suspicious of Kouta's behavior, while others remain oblivious, creating a mix of tension and humor. The series occasionally introduces new characters or scenarios that test the protagonists' relationship, further exploring themes of trust, acceptance, and the complexities of young love.

Throughout the manga, the fantastical premise serves as a metaphor for the vulnerabilities and quirks that make relationships unique. The interplay between Yuki's determination and Kouta's awkwardness drives the narrative, offering a blend of romance, comedy, and slice-of-life elements. The story maintains a light-hearted tone while occasionally touching on deeper emotional moments, making it an engaging exploration of love and friendship within a whimsical framework.