"Muteki Kanban Musume Napalm" centers on Miki Onimaru, a spirited and impulsive high school girl who works part-time at her family’s Chinese restaurant, Napalm. Despite her small stature, Miki possesses immense physical strength and a fiery temper, often leading to chaotic and comedic situations. Her primary role at the restaurant is delivering orders, but her aggressive approach to customer service frequently results in property damage and confrontations. Miki’s antics are fueled by her rivalry with the neighboring Italian restaurant, Trattoria Rigoletto, whose employees often clash with her over business and personal grievances.

The series thrives on slapstick humor and over-the-top action, with Miki’s deliveries frequently devolving into brawls or absurd challenges. Her interactions with other characters, such as her level-headed coworker Kankuro Ryuganji and the cunning Rigoletto delivery girl Akiko Oono, add layers of rivalry and camaraderie. The narrative explores Miki’s struggles to balance her chaotic personality with her responsibilities, often highlighting her growth as she navigates both her job and personal relationships. The story also delves into the dynamics of the restaurant industry, with exaggerated portrayals of competition and customer service.

Secondary characters, including Miki’s family and various eccentric customers, contribute to the series’ comedic tone. The plotlines are episodic, focusing on self-contained stories that build on the characters’ relationships and the escalating absurdity of their situations. Themes of perseverance, loyalty, and the importance of family and teamwork are woven into the narrative, though the primary focus remains on humor and action. The series blends workplace comedy with martial arts-inspired battles, creating a unique and energetic tone that drives its appeal.