"A Terrified Teacher at Ghoul School!" is a comedic horror manga that centers around Gou Kusano, a timid and ordinary human teacher who finds himself employed at a school populated entirely by supernatural creatures. The school, known as Kyoukai Gakuen, is a hidden institution where students are ghouls, vampires, werewolves, and other mythical beings. Gou, initially unaware of the school's true nature, is thrust into a world of chaos and absurdity as he struggles to maintain order and teach his monstrous students.

The narrative explores Gou's daily challenges as he navigates the bizarre and often dangerous behavior of his students. Despite his overwhelming fear, Gou gradually develops a sense of responsibility and begins to connect with the students, who, despite their terrifying appearances and abilities, exhibit relatable human emotions and struggles. Key characters include the mischievous vampire Shizuka, the stoic werewolf Koma, and the enigmatic ghost girl Yuki, each of whom adds depth to the story through their interactions with Gou and their unique personalities.

The plot balances humor and horror, with Gou frequently finding himself in over-the-top, life-threatening situations that are played for comedic effect. The manga delves into themes of acceptance and understanding, as Gou learns to see beyond the monstrous exteriors of his students and recognize their individuality. The series also incorporates elements of mystery, as Gou uncovers secrets about the school's origins and the true nature of its inhabitants. Through its blend of supernatural elements, slapstick comedy, and heartfelt moments, "A Terrified Teacher at Ghoul School!" offers a unique take on the teacher-student dynamic within an unconventional setting.