"Fall in Love Like a Comic!" centers on the life of Momose Ichigo, a high school student and aspiring manga artist who dreams of creating her own romantic shoujo manga. Despite her passion for storytelling, Ichigo struggles with her lack of real-life romantic experience, which she believes hinders her ability to write authentic love stories. Her world changes when she meets Hatori Togo, a popular and aloof classmate who unexpectedly becomes her muse. Togo, who harbors a secret passion for shoujo manga, offers to help Ichigo by acting as her "romantic consultant," providing her with insights and experiences to inspire her work.

As the two collaborate, their relationship evolves from a professional arrangement to a deeper, more personal connection. Ichigo begins to experience the emotions she once only imagined, while Togo gradually opens up about his own vulnerabilities and dreams. The story explores their growing bond, blending humor, heartfelt moments, and the challenges of balancing personal aspirations with budding romance. Supporting characters, such as Ichigo's best friend and fellow manga enthusiast, Ayumi, and Togo's childhood friend, Ritsu, add depth to the narrative, offering contrasting perspectives on love and creativity.

The manga delves into themes of self-discovery, artistic passion, and the complexities of young love. Ichigo's journey as a creator mirrors her emotional growth, as she learns to draw from her own experiences rather than relying solely on idealized fantasies. Togo's character arc reveals his struggles with societal expectations and his desire to pursue his true interests, creating a dynamic interplay between the two protagonists. The series balances lighthearted, comedic moments with poignant reflections on the creative process and the nuances of human relationships, making it a compelling exploration of both romance and personal ambition.