"Me & My Brothers" centers on Haruomi Yoshikawa, a high school student who unexpectedly becomes the guardian of his four younger brothers after their parents pass away. The brothers—Chihiro, Iori, Sora, and Asahi—each have distinct personalities and challenges, creating a dynamic and often chaotic household. Haruomi, despite his youth, takes on the responsibility of providing for his siblings, balancing school, part-time jobs, and the demands of parenting.

Chihiro, the eldest of the younger brothers, is serious and responsible, often helping Haruomi manage the household. Iori, the second brother, is cheerful and outgoing but struggles with self-doubt and a desire for independence. Sora, the third brother, is quiet and introspective, often lost in his own world, while Asahi, the youngest, is energetic and mischievous, requiring constant attention. Together, they navigate the complexities of family life, financial struggles, and personal growth.

The narrative explores themes of resilience, familial bonds, and the challenges of adolescence. Haruomi’s journey as a surrogate parent is marked by moments of frustration, sacrifice, and tenderness, as he learns to balance his own needs with those of his brothers. The brothers, in turn, grapple with their individual struggles, from school pressures to emotional insecurities, while relying on each other for support. The series portrays their everyday lives with a mix of humor, heartbreak, and warmth, highlighting the strength of their bond despite the hardships they face.

Throughout the story, the brothers encounter various external challenges, including financial instability, societal expectations, and interpersonal conflicts. Their interactions with classmates, neighbors, and extended family members add depth to the narrative, showcasing how their relationships evolve over time. The series emphasizes the importance of communication, understanding, and perseverance in overcoming adversity, offering a heartfelt portrayal of a non-traditional family unit striving to stay together against the odds.