"Gamers!" is a romantic comedy manga series that explores the lives of high school students whose interests in video games intertwine with their personal relationships. The story centers on Keita Amano, a reserved and introverted student who prefers solitary gaming over social interactions. His life takes a turn when Karen Tendo, the popular and attractive president of the school's Gaming Club, invites him to join. Despite his initial reluctance, Keita becomes entangled in the club's activities, leading to a series of misunderstandings and comedic situations.

Karen is a skilled gamer with a competitive streak, often challenging Keita to matches that highlight their differing playstyles. Alongside them is Tasuku Uehara, Karen's childhood friend and a member of the Gaming Club, who harbors unspoken feelings for her. Chiaki Hoshinomori, another club member, is a hardcore gamer with a blunt personality, often clashing with Keita's more casual approach to gaming. The group's dynamics are further complicated by the arrival of Aguri, Keita's classmate and Tasuku's girlfriend, who becomes inadvertently involved in the club's antics.

The narrative thrives on misunderstandings and miscommunications, as characters misinterpret each other's intentions and actions. Romantic tensions arise as Keita finds himself caught between Karen and Aguri, while Tasuku struggles with his feelings for Karen. The series delves into themes of friendship, rivalry, and the complexities of teenage relationships, all framed within the context of gaming culture. The characters' interactions are driven by their shared passion for video games, which serves as both a bonding tool and a source of conflict.

As the story progresses, the group navigates various challenges, including school events, gaming tournaments, and personal dilemmas. The humor stems from the characters' exaggerated reactions and the absurdity of their misunderstandings, creating a lighthearted yet engaging narrative. "Gamers!" balances its comedic elements with moments of genuine emotional depth, offering a relatable portrayal of adolescence and the impact of shared interests on interpersonal connections.