David Kaye is a highly accomplished Canadian voice actor, widely recognized for his extensive work in animation, anime, and video games. He began his career in Vancouver, British Columbia, during the 1980s, transitioning from radio and theater work into voice acting. His first voice-over role was in the 1989 animated series G.I. Joe. Over the following decades, he became a prominent figure in the Vancouver voice acting community before relocating to Los Angeles in 2007.

Kaye is particularly renowned for his contributions to English-dubbed anime. One of his most iconic and enduring roles is that of Sesshomaru, the powerful and stoic dog demon, in the popular series Inuyasha. He originated this role in the early 2000s and continued it in subsequent movies and video games. After a hiatus from anime dubbing following his move to Los Angeles, Kaye notably returned to the character for the sequel series, Yashahime: Princess Half-Demon, and its second act, Yashahime: Princess Half-Demon - The Second Act. This return was significant as it marked his first anime dub work in over a decade, facilitated by the production taking place at a studio in Los Angeles.

Beyond Sesshomaru, Kaye's anime filmography includes several other prominent roles from the golden age of English-dubbed anime. He voiced the calculating antagonist Treize Khushrenada in the seminal series Mobile Suit Gundam Wing. He also played the role of the hysterical father Soun Tendo in the classic comedy Ranma ½, a role listed in the provided credits for the series Team Ranma vs. The Legendary Phoenix. His other anime credits from this era include Recoome in the Ocean Group dub of Dragon Ball Z, Batou in Ghost in the Shell: Stand Alone Complex, and the Ancient One in Ronin Warriors. He also took on roles such as Akira Hojo in Sanctuary, Cyber-fly in Prince Mackaroo, Bolt Crank in Eat-Man '98, and Daisaku Sakaki in Kishin Corps.

In addition to his anime work, Kaye has an extensive and celebrated career in Western animation. He is perhaps best known for his long association with the Transformers franchise, where he first voiced the villainous Megatron in the CGI series Beast Wars: Transformers. He would go on to reprise the role of Megatron in several subsequent series, including Transformers: Armada, Transformers: Energon, and Transformers: Cybertron, sometimes as the upgraded Galvatron. In 2007, he achieved a unique distinction within the franchise by becoming the first actor to regularly voice both the primary villain, Megatron, and the primary hero, Optimus Prime, when he was cast as the latter in Transformers: Animated. His other major animation roles include Professor X in X-Men: Evolution, Clank in the Ratchet & Clank video game series, Khyber in Ben 10: Omniverse, Duckworth in the DuckTales reboot, and Max Tennyson in the Ben 10 reboot. He has also been the announcer for the HBO program Last Week Tonight with John Oliver since its inception.

Throughout his career, David Kaye has demonstrated significant range and longevity, building a body of work that spans multiple genres and decades. His ability to portray both iconic villains and beloved heroes has made him a familiar and respected voice to audiences worldwide. His return to the role of Sesshomaru for Yashahime highlights his lasting connection to a character he helped define for English-speaking fans.