"Kare Baka: Wagahai no Kare wa Baka de R" centers on the comedic and chaotic relationship between a high school girl and her eccentric, self-proclaimed genius boyfriend. The protagonist, a pragmatic and level-headed student, finds herself constantly exasperated by her boyfriend's absurd antics and over-the-top declarations of brilliance. Despite his grandiose claims, his actions often reveal a lack of common sense, leading to humorous misunderstandings and awkward situations. The series explores their daily interactions, highlighting the contrast between her grounded personality and his delusional self-confidence.

The boyfriend frequently attempts to impress her with his "intellectual prowess," often resulting in failure or embarrassment. His exaggerated sense of self-importance and tendency to misinterpret situations create a recurring cycle of comedic tension. The protagonist, while often frustrated, gradually develops a deeper understanding of his quirks and begins to appreciate his genuine, albeit misguided, efforts to make her happy. Supporting characters, including classmates and friends, add to the comedic dynamic, often reacting to the boyfriend's antics with a mix of amusement and disbelief.

The narrative structure relies heavily on episodic humor, with each episode presenting new scenarios that showcase the boyfriend's eccentricities and the protagonist's attempts to navigate their unconventional relationship. Themes of acceptance, individuality, and the complexities of romantic relationships are subtly woven into the comedic framework. The series balances slapstick comedy with moments of genuine warmth, offering a lighthearted yet relatable portrayal of young love and the challenges of understanding someone who sees the world differently.