"Makeruna! Makendo" is a comedic anime series centered around Makendo, a young boy who dreams of becoming a samurai despite his lack of skill and discipline. The story is set in a fictional version of feudal Japan, where Makendo's aspirations clash with his clumsy and carefree nature. His journey begins when he encounters a mysterious old man who gifts him a magical sword, the Makendo Blade, which grants him extraordinary powers. However, the sword's abilities are unpredictable and often lead to chaotic and humorous situations.

Makendo's adventures are driven by his desire to prove himself as a true samurai, but his efforts are frequently undermined by his own incompetence and the sword's erratic behavior. Along the way, he is joined by a colorful cast of characters, including his loyal but equally inept friends and a series of eccentric rivals. These characters often serve as foils to Makendo's antics, creating a dynamic and entertaining narrative filled with slapstick humor and over-the-top action.

The series explores themes of perseverance and self-improvement, as Makendo continually strives to overcome his shortcomings and live up to his ideals. Despite his many failures, his unwavering determination and good-hearted nature endear him to those around him. The episodic structure of the series allows for a variety of comedic scenarios, ranging from absurd battles with supernatural foes to lighthearted misadventures in everyday life.

Throughout the series, Makendo's growth is subtly highlighted, though his core personality remains consistent. The humor often arises from the contrast between his grandiose ambitions and his inability to achieve them, making "Makeruna! Makendo" a lighthearted and engaging watch. The blend of traditional samurai tropes with modern comedic sensibilities creates a unique tone that appeals to fans of both historical and contemporary anime.