"Dokodemo Makibao" centers on the adventures of Makibao, a spirited and determined racehorse with a unique ability to run at incredible speeds. Despite his small stature and unassuming appearance, Makibao possesses an indomitable spirit and a knack for overcoming seemingly insurmountable odds. The series is structured around episodic races and challenges, with Makibao frequently competing against larger, more powerful horses and rival jockeys. Each race serves as a platform to showcase Makibao's perseverance, cleverness, and heart, often leading to unexpected victories.

The narrative frequently highlights the bond between Makibao and his jockey, a young and inexperienced rider named Shingo. Shingo's growth as a jockey parallels Makibao's journey, with both characters learning from each other and evolving through their shared experiences. Their partnership is tested in various racing scenarios, from high-stakes competitions to unconventional challenges, often involving rival horses and jockeys with distinct personalities and motivations.

The series incorporates a mix of humor, action, and lighthearted drama, with recurring themes of teamwork, determination, and the underdog triumphing against adversity. Supporting characters, such as rival horses and jockeys, add depth to the story, each bringing their own quirks and challenges to the races. The episodic nature of the series allows for a variety of settings and scenarios, keeping the narrative dynamic and engaging.

Makibao's races are often marked by creative and exaggerated obstacles, adding a layer of unpredictability and excitement to the competitions. These elements, combined with the series' focus on character development and the central bond between Makibao and Shingo, create a compelling and entertaining narrative. The story consistently emphasizes the importance of resilience and the power of believing in oneself, making it a memorable and uplifting series within the sports anime genre.