"Poyopoyo" is a short-form anime series that revolves around the daily life of the Katsuragi family and their unusually round, orange tabby cat named Poyo. The series is structured as a slice-of-life comedy, with each episode consisting of several brief vignettes that highlight the quirky interactions between Poyo and the family members. The Katsuragi household includes Moe, a cheerful and slightly airheaded young girl; her older brother, Shigeru, who is often exasperated by Poyo's antics; and their parents, who are generally laid-back but occasionally get caught up in the chaos caused by the cat.

Poyo, the titular character, is depicted as a spherical, hyperactive cat with a mischievous yet endearing personality. His antics often lead to humorous situations, such as stealing food, causing minor household disasters, or engaging in playful battles with other neighborhood animals. Despite his troublemaking tendencies, Poyo is deeply loved by the family, and his presence brings a sense of warmth and humor to their everyday lives. The series also features recurring side characters, including a grumpy neighbor and a rival cat, who add variety to the comedic scenarios.

The narrative is episodic, with no overarching plot, focusing instead on the small, relatable moments of family life. The humor is lighthearted and relies heavily on visual gags, exaggerated expressions, and the absurdity of Poyo's spherical shape. The series captures the charm of living with a pet, emphasizing the joy and occasional frustration that comes with it. Through its simple yet effective storytelling, "Poyopoyo" offers a wholesome and entertaining portrayal of family dynamics and the unique bond between humans and their pets.