"Iya na Kao Sare Nagara Opantsu Misete Moraitai" is a short-form anime series that revolves around a group of high school girls who find themselves in humorous and awkward situations centered around the concept of showing their underwear. The narrative is episodic, with each episode focusing on a different character and her unique circumstances. The main characters include Nadeshiko, a shy and reserved girl; Tsukasa, a confident and outgoing classmate; and Yuuna, a mischievous and playful friend.

The series employs a comedic tone, often exaggerating the girls' reactions and the absurdity of the situations they encounter. Despite the seemingly risqué premise, the humor is lighthearted and relies on slapstick and situational comedy rather than overtly sexual content. The interactions between the characters highlight their distinct personalities, with Nadeshiko often being the reluctant participant, Tsukasa taking charge, and Yuuna adding chaos to the mix.

Each episode follows a similar structure, with the girls being placed in scenarios where they are pressured or tricked into revealing their underwear, often leading to comedic misunderstandings or over-the-top reactions. The series does not delve deeply into character development or overarching plotlines, instead focusing on delivering quick, self-contained comedic moments. The brevity of the episodes, typically lasting only a few minutes, aligns with the series' goal of providing fast-paced, light entertainment.

The setting is primarily a high school environment, with occasional scenes taking place in other locations such as parks or shopping districts. The simplicity of the setting allows the focus to remain on the characters and their interactions. The series does not explore complex themes or narratives, instead prioritizing humor and the dynamics between the main cast. Overall, "Iya na Kao Sare Nagara Opantsu Misete Moraitai" is a straightforward comedy that relies on its quirky premise and character-driven humor to entertain its audience.