"Kami-sama Minarai: Himitsu no Cocotama" is a children's anime series that revolves around the concept of Cocotama, small deities born from the gratitude of cherished objects. These deities, invisible to most humans, reside in the homes of those who take good care of their belongings. The story centers on Kokoro Yotsuba, a cheerful and slightly clumsy elementary school girl who discovers a Cocotama named Raibaru after cleaning her grandmother's old music box. Raibaru, along with other Cocotama like Kirara, Shabon, and Mekuru, forms a bond with Kokoro, guiding her through various challenges while learning about human emotions and responsibilities.

The Cocotama are in training to become full-fledged gods, and their growth depends on helping humans and earning "Thank Power," a form of energy generated by gratitude. Each episode typically features Kokoro and her Cocotama friends encountering everyday problems, such as school assignments, friendships, or family matters, which they resolve together. The Cocotama often use their unique abilities, like Raibaru's lightning powers or Kirara's ability to create sparkles, to assist Kokoro and others in their community.

The series emphasizes themes of kindness, responsibility, and the importance of taking care of one's possessions. It also explores the idea that even small acts of gratitude can have a significant impact. The Cocotama's interactions with Kokoro and her family provide lighthearted and educational moments, making the series accessible to younger audiences. Over time, Kokoro's relationship with the Cocotama deepens, and they collectively learn valuable lessons about cooperation, empathy, and the joy of helping others. The narrative maintains a gentle, episodic structure, with each episode offering a self-contained story while contributing to the overarching development of the characters.