"Gallery Fake" centers on Fujita Reiji, a former curator at the Metropolitan Museum of Art in New York, who now runs a small art gallery in Tokyo called "Gallery Fake." Fujita is a skilled art appraiser and dealer with a deep knowledge of art history, but his gallery specializes in dealing with forgeries, replicas, and lesser-known works. Despite his expertise, Fujita often operates in morally ambiguous ways, using his cunning and charm to navigate the art world's underbelly.

The episodic narrative explores various art-related cases, each involving unique challenges such as uncovering the origins of a piece, verifying its authenticity, or negotiating with collectors and criminals. Fujita frequently collaborates with Sara Halifa, a skilled art restorer, and Ryōko Saeba, a resourceful assistant, to solve these cases. The series delves into themes of art forgery, the value of art, and the ethical dilemmas surrounding the art trade.

Throughout the series, Fujita's past as a disgraced curator is gradually revealed, shedding light on his motivations and the reasons behind his fall from grace. His interactions with clients, rivals, and law enforcement often blur the lines between right and wrong, as he uses his knowledge to manipulate situations to his advantage. The stories are enriched by historical and cultural references, providing insight into famous artworks, artists, and art movements.

The characters are well-defined, with Fujita's sharp intellect and roguish charm making him a compelling protagonist. Sara's technical expertise and Ryōko's resourcefulness complement Fujita's skills, creating a dynamic team. The series balances intrigue, humor, and drama, offering a nuanced portrayal of the art world's complexities. Each episode stands alone, but recurring characters and overarching themes tie the narrative together, creating a cohesive exploration of art, authenticity, and human ambition.