"Higepiyo" is a surreal and comedic anime series centered around the bizarre and whimsical life of a man with a mustache that has taken on a life of its own. The protagonist, Higepiyo, is an ordinary salaryman whose mustache suddenly transforms into a sentient, anthropomorphic creature resembling a small, round bird. This mustache, also named Higepiyo, becomes a constant companion, often causing chaos and absurd situations in the protagonist's daily life.

The narrative unfolds in a series of episodic vignettes, each highlighting the strange and humorous interactions between Higepiyo and the protagonist. The mustache exhibits a mischievous and unpredictable personality, frequently leading to awkward or embarrassing scenarios for its host. Despite its antics, Higepiyo occasionally displays moments of loyalty and affection, creating a peculiar dynamic between the two.

The series explores mundane settings such as the workplace, home, and public spaces, but infuses them with surreal humor and unexpected twists. Supporting characters, including coworkers, family members, and strangers, react to the bizarre presence of Higepiyo in various ways, ranging from confusion to acceptance. The humor often stems from the contrast between the protagonist's attempts to maintain a normal life and the mustache's relentless interference.

Themes of absurdity, identity, and the unpredictability of life are woven into the narrative, though the series primarily focuses on delivering lighthearted and eccentric entertainment. The episodic structure allows for a wide range of comedic scenarios, ensuring that each episode offers a fresh and unpredictable experience. The simplicity of the premise is balanced by the creative execution, making "Higepiyo" a unique and memorable entry in the comedy genre.