"Urusei Yatsura Special: It's Spring! Take Off!" is a self-contained story set within the larger "Urusei Yatsura" universe, focusing on the comedic and chaotic lives of its central characters. The narrative revolves around Ataru Moroboshi, a perpetually unlucky and lecherous high school student, and Lum, a fiery alien princess from the Oni tribe who is deeply in love with him. The special is set during springtime, a season often associated with new beginnings and romantic tension, which serves as the backdrop for the unfolding events.

The story begins with Ataru attempting to enjoy the cherry blossom season, a traditional Japanese pastime, but his plans are quickly disrupted by Lum's overbearing affection and her jealousy over his flirtatious tendencies. Meanwhile, Shinobu, Ataru's childhood friend and former love interest, becomes entangled in the chaos when she tries to reconnect with him, sparking further misunderstandings. The arrival of additional characters, such as the mischievous alien Mendou and the eccentric priest Cherry, adds layers of absurdity to the situation.

A key plot point involves a mysterious springtime phenomenon that causes strange occurrences in Tomobiki Town, where the series is set. These events range from bizarre weather patterns to objects coming to life, creating a surreal and humorous atmosphere. The characters must navigate these anomalies while dealing with their interpersonal conflicts, particularly the ongoing love triangle between Ataru, Lum, and Shinobu. The special culminates in a series of comedic misunderstandings and slapstick moments, with Ataru's antics often serving as the catalyst for the chaos.

Throughout the story, the dynamic between Ataru and Lum remains central, with Lum's unwavering devotion contrasting sharply with Ataru's selfish and often clueless behavior. The supporting cast, including Shinobu, Mendou, and Cherry, each contribute to the comedic tone, with their unique quirks and interactions driving the narrative forward. The special maintains the lighthearted and whimsical tone characteristic of the "Urusei Yatsura" series, blending science fiction elements with traditional Japanese cultural references and slapstick humor. The episodic nature of the story ensures that it is accessible to both longtime fans and newcomers, offering a self-contained adventure that captures the essence of the franchise.