"What's Michael? 2" is a comedic slice-of-life anime that centers around the daily antics of Michael, an orange tabby cat, and his interactions with humans and other animals. The series is episodic, with each episode presenting self-contained stories that highlight Michael's quirky personality and the humorous situations he finds himself in. Michael's life alternates between two households: one with a young couple and another with a single salaryman. These settings provide a contrast in environments, showcasing how Michael adapts to different lifestyles and the varying dynamics of his human companions.

The young couple, often portrayed as affectionate and playful, treats Michael as a beloved pet, indulging his whims and often finding themselves at the mercy of his unpredictable behavior. In contrast, the salaryman's life is more solitary and routine, with Michael's presence adding a layer of chaos to his otherwise mundane existence. The series also features other cats and animals, each with distinct personalities, who interact with Michael in ways that further amplify the comedic tone.

The humor in "What's Michael? 2" stems from its exaggerated yet relatable portrayal of feline behavior, such as Michael's laziness, curiosity, and occasional mischief. The humans in the series are often depicted as bemused or exasperated by Michael's antics, creating a dynamic that underscores the universal appeal of pet ownership. The narrative does not follow a continuous plot but instead relies on vignettes that explore themes of companionship, everyday life, and the humorous misunderstandings that arise between humans and their pets.

The animation style is simple and straightforward, focusing on expressive character designs and fluid movements to convey the comedic timing and physical humor. The series maintains a lighthearted tone throughout, with occasional moments of absurdity that enhance its charm. By blending observational humor with a touch of surrealism, "What's Michael? 2" captures the essence of life with a cat, appealing to both pet owners and general audiences alike.