"What's Michael?" is a comedic slice-of-life anime centered around the daily antics of Michael, an orange tabby cat, and his interactions with various humans and other animals. The series presents a series of loosely connected vignettes rather than a continuous narrative, offering a humorous and often satirical look at the lives of cats and their owners. Michael is portrayed as a clever, mischievous, and sometimes aloof feline, embodying the quintessential cat personality. His behavior ranges from endearing to absurd, capturing the quirks and unpredictability of real-life cats.

The humans in the series are depicted as ordinary individuals whose lives are frequently disrupted or influenced by Michael and other cats. These characters include a young couple, office workers, and a yakuza member, among others. Each episode explores different scenarios, such as Michael causing chaos in a household, navigating the challenges of outdoor life, or interacting with other animals. The humor often arises from the contrast between the humans' attempts to impose order and the cats' instinctual, carefree behavior.

The series also delves into the lives of other cats, providing a broader perspective on feline behavior. These cats, like Michael, exhibit distinct personalities and engage in their own humorous or poignant adventures. The anime balances lighthearted comedy with occasional moments of reflection on the bond between humans and animals, though it primarily maintains a playful tone.

The episodic structure allows for a variety of settings and situations, from domestic environments to urban streets, ensuring a dynamic and engaging viewing experience. The humor is accessible, relying on universal themes of pet ownership and animal behavior, making it relatable to a wide audience. The characters, both human and feline, are portrayed with a mix of realism and exaggeration, enhancing the comedic and observational aspects of the series. Overall, "What's Michael?" offers a charming and entertaining exploration of the everyday lives of cats and their human companions.