"Jigoku Sensei Nube: Gozen 0 toki Nube Shisu" is a supernatural anime series that serves as a sequel to the original "Jigoku Sensei Nube." The story centers on Meisuke Nueno, also known as Nube, a teacher at Domori Elementary School who possesses a demonic left hand sealed with a talisman. This hand grants him extraordinary powers to combat malevolent spirits and supernatural threats. The narrative begins with Nube facing a dire prophecy: he is destined to die at midnight on his 30th birthday. As the clock ticks toward this fateful moment, Nube must confront increasingly dangerous supernatural forces while protecting his students and loved ones.

The series delves into Nube's past, revealing the origins of his cursed hand and the sacrifices made by those who came before him to seal its power. As the deadline approaches, Nube's students, particularly Ritsuko Takahashi and Hiroshi Tateno, become deeply involved in the battle against evil spirits. Their loyalty and courage are tested as they assist Nube in his mission to protect the school and the town from supernatural threats. The story also introduces new characters, such as the enigmatic Kyoichi Sakata, who plays a pivotal role in the unfolding events.

The plot intensifies as Nube uncovers a conspiracy tied to his impending death, involving powerful entities from the spirit world. These entities seek to exploit his cursed hand for their own nefarious purposes. The series balances episodic supernatural encounters with an overarching narrative, building tension as Nube's final hour draws near. Themes of sacrifice, friendship, and the struggle between good and evil are explored as Nube grapples with his fate and the responsibilities of his powers. The story culminates in a climactic battle that determines not only Nube's destiny but also the safety of the world he has sworn to protect.