"Dokushin Apart Dokudamiso" is a slice-of-life comedy anime centered around the lives of three single men living in a small apartment complex called Dokudamiso. The narrative explores their daily routines, personal quirks, and interactions with each other and their neighbors, blending humor with relatable moments of adult life.

The main characters include Shintaro Kisaragi, a reserved and somewhat socially awkward office worker; Hajime Tsukishima, a carefree and easygoing man who often acts as the group's mediator; and Takao Fujimaki, a passionate but clumsy individual with a penchant for overthinking. Each character brings a distinct personality to the group dynamic, creating a balance of comedic tension and camaraderie.

The plot unfolds through episodic vignettes, focusing on mundane yet humorous situations such as failed attempts at cooking, awkward encounters with neighbors, and the challenges of maintaining a work-life balance. The apartment complex itself serves as a microcosm of their lives, with recurring side characters like the nosy landlady and eccentric neighbors adding depth to the setting. The series avoids dramatic conflicts, instead emphasizing the charm of everyday life and the small joys and struggles of being single adults.

The humor is largely situational, deriving from the characters' contrasting personalities and their often exaggerated reactions to ordinary events. While the tone is lighthearted, the series occasionally touches on themes of loneliness, self-discovery, and the importance of human connection, providing a subtle emotional undercurrent to the comedy. The narrative structure is straightforward, with each episode offering a self-contained story that contributes to the overall portrayal of the characters' lives.