"Unlucky Fukōda-sensei" centers on the life of Fukōda, a high school teacher whose name literally translates to "unlucky." True to his name, Fukōda is perpetually plagued by misfortune, often finding himself in absurd and comedic situations. Despite his best efforts to maintain professionalism and dignity, his bad luck frequently disrupts his daily life, creating a series of humorous and chaotic events.

The narrative unfolds in a high school setting, where Fukōda attempts to navigate his teaching responsibilities while dealing with his relentless streak of bad luck. His misfortunes range from minor inconveniences, like spilling coffee on himself, to more extreme scenarios, such as accidentally causing school-wide disruptions. The students and faculty often witness these incidents, leading to a mix of sympathy, amusement, and occasional frustration from those around him.

Fukōda's character is defined by his resilience and determination to persevere despite his constant setbacks. He is portrayed as a well-meaning and dedicated teacher who genuinely cares for his students, but his efforts are frequently undermined by his unlucky nature. The students, while sometimes bewildered by his antics, generally respect and appreciate him, often finding themselves drawn into his misadventures.

The series employs a episodic structure, with each chapter presenting a new scenario where Fukōda's bad luck takes center stage. These scenarios are often exaggerated for comedic effect, blending slapstick humor with situational comedy. The interactions between Fukōda and his students, as well as his colleagues, add depth to the narrative, highlighting the dynamics of school life and the impact of Fukōda's personality on those around him.

Supporting characters include a variety of students and teachers, each contributing to the comedic and sometimes heartfelt moments in the series. The students, in particular, play a significant role in both causing and resolving Fukōda's predicaments, showcasing their own unique personalities and quirks. The faculty members, while occasionally exasperated by Fukōda's misfortunes, also provide a sense of camaraderie and support, emphasizing the collaborative nature of the school environment.

Overall, "Unlucky Fukōda-sensei" is a lighthearted and entertaining exploration of perseverance in the face of constant adversity. Through its comedic lens, the series offers a humorous yet relatable portrayal of the challenges and joys of teaching, as well as the unpredictable nature of life.