A world exists where strange and endearing creatures with slightly unusual characteristics live alongside everyday life. These beings, known as Henteko Ikimono, are defined by their peculiar but comforting traits. Among them is Naderyu, a dragon said to bring happiness to anyone who strokes it. There is also Nekozame, a shark that possesses the cute face of a cat, and Mae-muki Kiwi, a kiwi that maintains a positive and forward-looking attitude even after being cut. The core premise suggests that these weird creatures might be hiding right next to ordinary people, waiting to be discovered.

The manga focuses on introducing a variety of these creatures rather than following a single continuous plotline. The main characters are the Henteko Ikimono themselves, each presented as a distinct entity with a specific quirk or healing property. The setting is the real world, implying that these fantastic animals exist in the margins of human society. Notable narrative arcs are not present in the source material, as the work appears to be structured as a collection of creature profiles and short vignettes designed to provide comfort and amusement through their odd charm.