"Potemayo" is a slice-of-life comedy manga series that revolves around the daily lives of a group of quirky characters, blending surreal humor with heartwarming moments. The story centers on Sunao Moriyama, a reserved high school student whose mundane life takes an unexpected turn when he discovers a small, cat-like creature in his refrigerator. This creature, named Potemayo, is a mysterious being with a childlike personality, a fondness for food, and a tendency to cause mischief. Despite her odd appearance and behavior, Potemayo quickly becomes an integral part of Sunao's life, bringing both chaos and companionship.

As the narrative progresses, Potemayo's presence introduces a series of comedic and absurd situations. Sunao's interactions with Potemayo are often marked by her innocent yet unpredictable antics, which challenge his patience but also gradually deepen their bond. The story expands to include other characters, such as Mikan, a classmate of Sunao who harbors feelings for him and becomes entangled in Potemayo's antics. Mikan's attempts to navigate her feelings for Sunao while dealing with Potemayo's interference add a layer of romantic tension and humor to the series.

Another key character is Guchuko, a rival creature similar to Potemayo but with a more aggressive and competitive personality. Guchuko's arrival introduces a dynamic of rivalry and camaraderie between the two creatures, often leading to exaggerated and comedic confrontations. The interactions between Potemayo and Guchuko, as well as their relationships with Sunao and the other characters, form the core of the series' humor and charm.

The manga balances its surreal elements with grounded, everyday scenarios, creating a whimsical yet relatable atmosphere. The characters navigate school life, friendships, and personal growth, all while dealing with the unpredictable presence of Potemayo and Guchuko. The series thrives on its ability to juxtapose the ordinary with the absurd, resulting in a lighthearted and entertaining narrative that appeals to fans of slice-of-life and comedy genres. Through its quirky characters and humorous situations, "Potemayo" offers a unique and endearing take on the complexities of relationships and the joy found in life's small, unexpected moments.