"Helen Keller Monogatari: Ai to Hikari no Tenshi" is an anime series that dramatizes the life of Helen Keller, a historical figure renowned for overcoming severe disabilities to become an influential advocate for the disabled. The narrative begins with Helen's early childhood in Tuscumbia, Alabama, where an illness leaves her deaf and blind. Her parents, Captain Arthur Keller and Kate Adams Keller, struggle to communicate with her, leading to frustration and isolation for Helen. The story highlights her transformation after the arrival of Anne Sullivan, a determined and innovative teacher who becomes Helen's mentor and lifelong companion.

Anne Sullivan, herself visually impaired, employs unconventional methods to break through Helen's barriers. A pivotal moment occurs when Anne teaches Helen the concept of language by spelling words into her hand, starting with "water" at a pump. This breakthrough unlocks Helen's ability to learn and communicate, marking the beginning of her intellectual and emotional growth. The series portrays Helen's journey as she learns to read Braille, write, and eventually speak, showcasing her relentless determination and Anne's unwavering support.

The anime also explores Helen's education at institutions like the Perkins School for the Blind and her later studies at Radcliffe College, where she becomes the first deaf-blind person to earn a Bachelor of Arts degree. Alongside her academic achievements, the series delves into her advocacy work, including her efforts to raise awareness about disabilities and her collaborations with figures like Alexander Graham Bell and Mark Twain. The bond between Helen and Anne remains a central theme, emphasizing their mutual reliance and the profound impact of their partnership.

Through its portrayal of Helen Keller's life, the series emphasizes themes of perseverance, the power of education, and the importance of human connection. It presents a detailed and heartfelt account of her struggles and triumphs, offering a respectful and inspiring depiction of her legacy.