"Zetsumetsu Kigu-shun–" is a Japanese anime series that revolves around the concept of endangered species and their anthropomorphized representations. The narrative centers on a group of anthropomorphic animals, each representing a species on the brink of extinction, who come together to prevent their own demise. These characters, known as the "Endangered Species," are tasked with combating a mysterious force that threatens their existence and the balance of the natural world.

The protagonist, Shishigari, is a lion representing the critically endangered Barbary lion. Shishigari is joined by other key characters such as Tonakai, a Hokkaido wolf; Kaba, a pygmy hippopotamus; and Shimauma, a Przewalski's horse. Each character embodies the traits and struggles of their respective species, blending ecological themes with personal growth and camaraderie. The group is guided by a human researcher, Dr. Kurosawa, who provides scientific insight and support in their mission.

The plot unfolds as the Endangered Species discover a sinister organization, known as the Extinction Syndicate, which seeks to accelerate the extinction of vulnerable species for its own gain. The Syndicate employs advanced technology and manipulation of natural forces to achieve its goals, posing a significant threat to the protagonists. The series explores the conflict between the Endangered Species and the Syndicate, with each episode delving into the challenges faced by the characters as they strive to protect their kind and the environment.

Throughout the series, the narrative emphasizes themes of conservation, resilience, and the interconnectedness of life. The characters' journeys are marked by moments of tension, teamwork, and self-discovery, as they confront both external adversaries and internal doubts. The story balances action-packed sequences with reflective moments, highlighting the urgency of preserving biodiversity while maintaining an engaging and accessible tone for viewers.