The third season of Wooser's Hand-to-Mouth Life follows the round, yellow creature Wooser, whose existence revolves around his three favorite things: money, meat, and girls. The season begins with Wooser returning to Earth after a shocking deep-space battle that concluded the previous arc. Stranded in a distant galaxy, he is guided back home by the Ultra Hero Ultraman Zero, crash-landing on a beach where his mundane yet bizarre adventures resume.

The main characters include Wooser, voiced by Mamoru Miyano, a self-centered layabout who is both crude and strangely endearing. His companions are Rin and Len, twin girls who inexplicably tolerate and care for him, along with their friend Miho and the quiet Yuu. A key figure is Darth Wooser, a dark grey robotic version of Wooser. Originally a silent presence, Darth Wooser emerges as a prominent character this season, acting as a snarky foil to his master. He is programmed to self-destruct if he directly insults Wooser, a fact the lazy protagonist exploits for his own amusement. Other recurring creatures include the chicken-like Ajipon and The Animal Whose Name Must Not Be Spoken.

The setting is a surreal and absurdist version of modern Japan, where the laws of reality are flexible. The 13-episode season, with each episode running approximately eight minutes, shifts away from pure stream-of-consciousness comedy to present more structured, coherent storylines. The narrative is episodic, with each installment parodying a different genre or aspect of otaku culture.

Notable narrative arcs and episodes include Wooser splitting himself into 53 copies to form an idol group called Wooser53 with the help of the character Miss Monochrome. He attempts to become a film director to win a contest for money, and later transforms into a giant grasshopper, forcing Rin and Len to become magical girls to stop him. In another episode, he plays a tense game of Werewolf, and in a parody of Sherlock Holmes, he turns detective to solve the locked-room murder of Ajipon. The season features frequent crossovers with characters from other franchises, including Arpeggio of Blue Steel and Miss Monochrome. The finale, directed by Gen Urobuchi, is a homage to the films Blade Runner and John Carpenter's The Thing, depicting a snowball fight that turns into a paranoid hunt for a shape-shifting alien. The series concludes with Wooser and his friends performing the ending theme song, Lucky Girl, by the artist Yunchi.