"Neko Kikaku" centers on a group of individuals who discover a mysterious organization dedicated to transforming humans into anthropomorphic cats. The protagonist, a young office worker named Haru, stumbles upon this organization after encountering a strange flyer promising a life free from societal pressures. Intrigued, Haru attends a meeting and is introduced to the Neko Kikaku project, which claims to offer participants a chance to escape their mundane lives by undergoing a transformation into a cat-human hybrid. The process, however, is irreversible and comes with unforeseen consequences.

As Haru delves deeper into the project, they meet other participants, each with their own reasons for joining. Among them is Aoi, a disillusioned artist seeking inspiration, and Riku, a former athlete grappling with a career-ending injury. The organization, led by the enigmatic Dr. Kuro, presents itself as a benevolent force, but its true motives remain shrouded in secrecy. The series explores the psychological and emotional struggles of the characters as they adapt to their new identities, grappling with the loss of their humanity and the societal stigma attached to their transformations.

The narrative takes a darker turn as the participants begin to experience side effects, including heightened aggression and a loss of control over their feline instincts. Tensions rise within the group as they question the ethics of the project and Dr. Kuro's intentions. Haru, Aoi, and Riku form an uneasy alliance to uncover the truth behind Neko Kikaku, leading them to confront the organization's hidden experiments and the ethical dilemmas surrounding human-animal hybridization.

The series balances its exploration of identity, autonomy, and societal alienation with moments of tension and mystery. The characters' relationships evolve as they navigate their new realities, with some embracing their feline traits while others struggle to retain their humanity. The story culminates in a confrontation with Dr. Kuro, revealing the extent of the organization's ambitions and the true cost of the transformations. "Neko Kikaku" ultimately examines the boundaries of human identity and the consequences of pursuing an idealized escape from reality.